Microbial mass spectrometer

Product Introduction:

The ZhiGong Bio Microbial Mass Spectrometer NAE-9600 (Medical Device Registration No. 20242220981) is a specialized analytical instrument designed to address key challenges in clinical microbiological testing. Leveraging the core technology of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), it achieves rapid and accurate identification of pathogenic microorganisms by analyzing their unique protein fingerprint profiles.

Detection principle:

The NAE-9600 microbial mass spectrometer is based on the core MALDI‑TOF MS technology. After co-crystallization of the microbial sample with a matrix, laser‑induced ionization generates ions corresponding to the microorganism’s structural proteins—primarily ribosomal proteins. Ions with different mass-to-charge ratios (m/z) enter a vacuum flight tube, where they are separated according to their differing flight times. A detector records these ion flight times and converts them into a characteristic protein profile, which is then compared against reference profiles in a database, enabling rapid and accurate identification of pathogenic microorganisms.

Product Features:

Core architecture and technological optimization deliver outstanding detection performance.

★ Featuring a 5° laser incidence angle design, it effectively minimizes the “shadow effect” and reduces the initial dispersion of ions. With direct, non‑networked transmission of single‑channel ions, laser light, and imaging signals, it enhances detection sensitivity and resolution.

★ Equipped with dual-pulse delay extraction technology, it supports pulse voltage outputs ranging from 0 to ±2500 V, continuous adjustment of pulse width, and zero‑jitter delay triggering, enabling full‑range resolution optimization and effectively addressing resolution deficiencies in specific mass ranges.

The laser system is stable and durable, with highly efficient energy transmission.

★ Equipped with a high‑frequency solid‑state laser, boasting a lifespan of 2 billion pulses, ensuring long‑term, stable operation of the equipment;

★ It employs an integrated, long‑distance micro‑focused optical path that minimizes energy loss, ensuring stable delivery of laser energy to the sample. Moreover, the spot size (80–300 μm) and energy (0–20 μJ) are continuously adjustable, guaranteeing optimal ionization efficiency and consistent analytical performance.

The strain library is of high quality and has broad coverage.

★ Collaborated with multiple domestic microbial strain preservation centers, hospitals, and disease control agencies to build a database.

★ Contains over 480 genera and more than 3,000 microbial strains, with continuous updates;

★ At least 24 high-quality spectra are acquired and combined for each strain to ensure spectral accuracy.

★ Covers the vast majority of common bacterial species encountered in clinical and public health settings, fully meeting routine identification needs.

Application areas

Rapid identification of clinical pathogens; infection control and epidemiological investigations; microbiological quality control in the pharmaceutical and food industries; microbial research and biotechnology development; public health and environmental monitoring.