Nucleic acid mass spectrometer

Product Introduction:

The ZhiGong Bio Nucleic Acid Mass Spectrometer NTSPECTOF 9600 is a high-throughput, fully automated multiplex molecular diagnostics platform dedicated to nucleic acid analysis. Built on the core technology of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), the system achieves rapid and precise analysis of various nucleic acid biomarkers—including single-nucleotide polymorphisms (SNPs), gene mutations, methylation modifications, and pathogen typing—by measuring the exact molecular masses of nucleic acid fragments. It provides an integrated nucleic acid analysis solution for clinical diagnostics, public health surveillance, and life sciences research.

Detection principle:

NTSPECTOF 9600, based on MALDI‑TOF MS technology, generates nucleic acid fragments of specific molecular weights by performing PCR amplification of the target sequence followed by either single‑base extension or site‑specific enzymatic digestion. After co-crystallizing the sample with a matrix, laser‑induced ionization produces ions from the nucleic acid fragments. Ions with different mass-to-charge ratios (m/z) are separated in a vacuum flight tube according to their differing migration times. A detector records these ion arrival times and converts them into a molecular‑weight profile of the nucleic acid fragments. Finally, analysis software compares this profile with theoretical molecular weights to achieve precise identification of nucleic acid variant sites.

Product Features:

Integrated, fully automatic design for convenient and efficient operation.

★ Utilizes a rodless, all-in-one platform that integrates automated spotting and mass spectrometry analysis, offering a high degree of automation and effectively reducing the failure rate.

★ Supports 96‑well throughput, suitable for clinical laboratories and a wide range of applications, meeting high‑throughput testing requirements.

High resolution and a wide detection range expand application potential.

★ High-resolution design, combined with an optimized detection range for nucleic acid assays, ensures the accuracy of nucleic acid fragment analysis.

★ Supports extended applications such as methylation analysis, providing a powerful tool for epigenetic research.

Single-use silicon-based chips, eliminating cross-contamination.

★ A disposable silicon-based chip is used in place of the conventional stainless steel target plate; the chip features a compact, precise design that facilitates high-throughput screening.

★ Single-use design effectively reduces the risk of sample cross-contamination, significantly enhancing the reliability of test results.

Intelligent software and expert support accelerate method development.

★ The software features a user-friendly design, with functions such as chip logging and time reminders, streamlining the operation process.

★ Equipped with dedicated primer design software, enabling intelligent design workflows and reducing the complexity of method development.

Application areas

Genetic disease screening and diagnosis, tumor gene mutation testing, pharmacogenomic analysis, pathogen typing and antimicrobial resistance testing, public health and epidemiological surveillance.